Abstract
Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
MeSH terms
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Administration, Oral
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Animals
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Crystallography, X-Ray
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Cyclin-Dependent Kinase 2 / antagonists & inhibitors*
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Cyclin-Dependent Kinase 2 / drug effects
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Dogs
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Drug Screening Assays, Antitumor
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Haplorhini
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Mice
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Models, Animal
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Models, Molecular
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Molecular Structure
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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Pyridines / chemical synthesis
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Rats
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Xenograft Model Antitumor Assays
Substances
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Pyrazoles
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Pyridines
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pyrazolo(3,4-b)pyridine
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Cyclin-Dependent Kinase 2